Metrological Support in the Field for the Development of Reference Materials of Isothermal Titration Calorimetry: Prospects

Isothermal titration calorimetry (ITC) allows studying the thermal effects of various chemical and physicochemical processes, including dissolution processes. This method is relatively new. Therefore, active expansion scope its application has revealed a number problems. For instance, article raises problem insufficient metrological support for isothermal calorimeters, which leads to inconsistency results obtained on different models as well their with literature data. The current electrical calibration procedures calorimeters are not universal have limitations in application. purpose research develop basic approaches creation certified reference materials value heat interactions established traceability base SI units. In course study, analysis state field ITC measurements was carried out, main requirements candidate substances RMs were formulated; target uncertainty integral dilution propanol-1 solutions estimated by analyzing characteristics working measuring instruments, made it possible establish measurement applied characterize RMs. A determining that provides State primary special standard unit reactions GET 133 been proposed tested. order implement project, necessary continue obtain experimental data characterization, assessment homogeneity stability material, processing results, estimating value, will make complete development materials.